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Issue 82, 2018
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A ratiometric fluorescent probe for peroxynitrite prepared by de novo synthesis and its application in assessing the mitochondrial oxidative stress status in cells and in vivo

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Abstract

A ratiometric fluorescent probe Cy-NEt2 for detecting ONOO is designed and prepared by de novo synthesis, which is a reliable, cheap and flexible route. The probe is applied for monitoring the level of mitochondrial ONOO and assessing the lipopolysaccharide (LPS)-induced mitochondrial oxidative stress status in living cells and in vivo successfully.

Graphical abstract: A ratiometric fluorescent probe for peroxynitrite prepared by de novo synthesis and its application in assessing the mitochondrial oxidative stress status in cells and in vivo

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Publication details

The article was received on 11 Sep 2018, accepted on 18 Sep 2018 and first published on 20 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC07389A
Citation: Chem. Commun., 2018,54, 11590-11593
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    A ratiometric fluorescent probe for peroxynitrite prepared by de novo synthesis and its application in assessing the mitochondrial oxidative stress status in cells and in vivo

    D. Zhou, Y. Li, W. Jiang, Y. Tian, J. Fei and C. Li, Chem. Commun., 2018, 54, 11590
    DOI: 10.1039/C8CC07389A

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