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Issue 90, 2018
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A four-component radical cascade trifluoromethylation reaction of alkenes enabled by an electron-donor–acceptor complex

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Abstract

An efficient four-component radical cascade reaction of alkenes, enabled by an EDA complex between Togni's reagent and Hantzsch ester, has been reported. This operationally simple protocol demonstrates excellent selectivity, which is dominated by the innate polar effect, providing facile access to important δ-CF3 carbonyls under mild conditions. To further demonstrate the wide synthetic utility of this method, a three-step synthesis of CF3-naftidrofuryl has been successfully conducted.

Graphical abstract: A four-component radical cascade trifluoromethylation reaction of alkenes enabled by an electron-donor–acceptor complex

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Publication details

The article was received on 10 Sep 2018, accepted on 15 Oct 2018 and first published on 15 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC07344A
Citation: Chem. Commun., 2018,54, 12710-12713
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    A four-component radical cascade trifluoromethylation reaction of alkenes enabled by an electron-donor–acceptor complex

    H. Tu, S. Zhu, F. Qing and L. Chu, Chem. Commun., 2018, 54, 12710
    DOI: 10.1039/C8CC07344A

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