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Issue 82, 2018
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Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models

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Abstract

A series of pyrazine and quinoxaline probes (QNNs) were synthesized and evaluated. The quinoxaline derivative 3b, with high affinity and selectivity for tau aggregates, favorable fluorescence turn-on capability and brain kinetics, was successfully applied to the detection of tau tangles both in vitro and in mice in vivo.

Graphical abstract: Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models

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Publication details

The article was received on 24 Aug 2018, accepted on 03 Sep 2018 and first published on 03 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06897F
Citation: Chem. Commun., 2018,54, 11558-11561
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    Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models

    B. Zhu, T. Zhang, Q. Jiang, Y. Li, Y. Fu, J. Dai, G. Li, Q. Qi and Y. Cheng, Chem. Commun., 2018, 54, 11558
    DOI: 10.1039/C8CC06897F

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