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A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives

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Abstract

A stereoselective multicomponent approach leading to a novel class of pentasubstituted tetrahydropyridines is described. Variation of the components enabled the incorporation of peptide, sugar and steroid moieties to access chimeric derivatives. DFT calculations provide insights about the unprecedented high diastereoselectivity of the MCR.

Graphical abstract: A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives

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Publication details

The article was received on 24 Aug 2018, accepted on 30 Oct 2018 and first published on 30 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC06871B
Citation: Chem. Commun., 2018, Advance Article
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    A stereoselective sequential organocascade and multicomponent approach for the preparation of tetrahydropyridines and chimeric derivatives

    R. Echemendía, G. P. da Silva, M. Y. Kawamura, A. F. de la Torre, A. G. Corrêa, M. A. B. Ferreira, D. G. Rivera and M. W. Paixão, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06871B

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