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Issue 82, 2018
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Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)

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Abstract

Perturbations of domain–domain interactions impact the function of type I fatty acid synthases. We identify interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain–domain binding energetics. Engineering of similar interfaces in related megasynthases may be exploited for custom synthesis of natural products.

Graphical abstract: Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)

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Publication details

The article was received on 22 Aug 2018, accepted on 14 Sep 2018 and first published on 25 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06838K
Citation: Chem. Commun., 2018,54, 11606-11609
  • Open access: Creative Commons BY license
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    Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)

    E. Rossini, J. Gajewski, M. Klaus, G. Hummer and M. Grininger, Chem. Commun., 2018, 54, 11606
    DOI: 10.1039/C8CC06838K

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