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Issue 98, 2018
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Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?

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Abstract

Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP). Mutant hIAPP with iso-aspartic residue mutations at possible deamidation sites showed very different fibril formation behaviour, which correlates with the observed deamidation-induced acceleration of hIAPP aggregation.

Graphical abstract: Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?

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Publication details

The article was received on 16 Aug 2018, accepted on 17 Nov 2018 and first published on 19 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC06675B
Citation: Chem. Commun., 2018,54, 13853-13856
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    Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?

    Y. P. Y. Lam, C. A. Wootton, I. Hands-Portman, J. Wei, C. K. C. Chiu, I. Romero-Canelon, F. Lermyte, M. P. Barrow and P. B. O’Connor, Chem. Commun., 2018, 54, 13853
    DOI: 10.1039/C8CC06675B

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