Issue 79, 2018

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

Abstract

Herein we report the transformation of readily synthesised acyl hydrazides into 2-hydrazobenzophenones via a novel molecular rearrangement pathway using aryne chemistry. The developed reaction protocol is performed under relatively mild conditions and is tolerant of a wide variety of functional groups, and the 2-hydrazobenzophenone products provide access to both 1H- and 2H-indazoles from a single intermediate.

Graphical abstract: A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

Supplementary files

Article information

Article type
Communication
Submitted
11 Aug 2018
Accepted
11 Sep 2018
First published
11 Sep 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 11180-11183

A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

A. Shamsabadi and V. Chudasama, Chem. Commun., 2018, 54, 11180 DOI: 10.1039/C8CC06556J

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