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Issue 98, 2018
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Photoactivatable platinum anticancer complex can generate tryptophan radicals

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Abstract

L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.

Graphical abstract: Photoactivatable platinum anticancer complex can generate tryptophan radicals

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Publication details

The article was received on 10 Aug 2018, accepted on 24 Oct 2018 and first published on 23 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC06496B
Citation: Chem. Commun., 2018,54, 13845-13848
  • Open access: Creative Commons BY license
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    Photoactivatable platinum anticancer complex can generate tryptophan radicals

    C. Vallotto, E. Shaili, H. Shi, J. S. Butler, C. J. Wedge, M. E. Newton and P. J. Sadler, Chem. Commun., 2018, 54, 13845
    DOI: 10.1039/C8CC06496B

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