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Issue 80, 2018
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A synthetic model of the nonheme iron–superoxo intermediate of cysteine dioxygenase

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Abstract

A nonheme Fe(II) complex (1) that models substrate-bound cysteine dioxygenase (CDO) reacts with O2 at −80 °C to yield a purple intermediate (2). Analysis with spectroscopic and computational methods determined that 2 features a thiolate-ligated Fe(III) center bound to a superoxide radical, mimicking the putative structure of a key CDO intermediate.

Graphical abstract: A synthetic model of the nonheme iron–superoxo intermediate of cysteine dioxygenase

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Publication details

The article was received on 01 Aug 2018, accepted on 17 Sep 2018 and first published on 24 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06247A
Citation: Chem. Commun., 2018,54, 11344-11347

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    A synthetic model of the nonheme iron–superoxo intermediate of cysteine dioxygenase

    A. A. Fischer, S. V. Lindeman and A. T. Fiedler, Chem. Commun., 2018, 54, 11344
    DOI: 10.1039/C8CC06247A

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