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Issue 77, 2018
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Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

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Abstract

Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.

Graphical abstract: Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

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Article information


Submitted
30 Jul 2018
Accepted
03 Sep 2018
First published
06 Sep 2018

Chem. Commun., 2018,54, 10890-10892
Article type
Communication

Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl2

O. Shemchuk, L. Song, K. Robeyns, D. Braga, F. Grepioni and T. Leyssens, Chem. Commun., 2018, 54, 10890
DOI: 10.1039/C8CC06199H

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