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Issue 82, 2018
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Pyrazolone: a powerful synthon for asymmetric diverse derivatizations

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As a powerful synthon, pyrazolone has widely been exploited for the construction of various chiral pyrazoles/pyrazolones which hold great potential in the development of pharmaceutical chemistry, coordination chemistry and functional materials. Benefited from the diversity and multiple active sites of the starting materials, such as 4-nonsubstituted/4-monosubstituted pyrazolones and α,β-unsaturated pyrazolones, large numbers of strategies for the asymmetric synthesis of various pyrazoles/pyrazolones have been developed successfully in the past few years. This feature article summarizes these excellent research studies since 2015, including some efforts by our group. Based on the structural feature of the final products, this feature article is divided into four sections, including the catalytic asymmetric synthesis of 4-monosubstituted, 4-disubstituted, fused and spiro pyrazoles/pyrazolones. Schematic illustrations are given for some representative examples in each section.

Graphical abstract: Pyrazolone: a powerful synthon for asymmetric diverse derivatizations

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Publication details

The article was received on 30 Jul 2018, accepted on 10 Sep 2018 and first published on 10 Sep 2018

Article type: Feature Article
DOI: 10.1039/C8CC06196C
Citation: Chem. Commun., 2018,54, 11515-11529

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    Pyrazolone: a powerful synthon for asymmetric diverse derivatizations

    S. Liu, X. Bao and B. Wang, Chem. Commun., 2018, 54, 11515
    DOI: 10.1039/C8CC06196C

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