Issue 78, 2018

Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles

Abstract

A copper-catalyzed functionalization of inert cyclic ethers was developed to provide α-aminonitriles via a cascade oxidation/amination/ring-opening/cyanation reaction. A series of highly versatile α-aminonitriles were obtained from primary or secondary anilines, and heterocyclic and aliphatic amines with high yields. This process features excellent functional group tolerance, a broad substrate scope, and high activity under ambient conditions.

Graphical abstract: Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles

Supplementary files

Article information

Article type
Communication
Submitted
27 Jul 2018
Accepted
06 Sep 2018
First published
06 Sep 2018

Chem. Commun., 2018,54, 11033-11036

Copper-catalyzed amination of an α-C(sp3)–H bond in inactivated ethers to synthesize α-aminonitriles

Z. Yuan, C. Zhu, Z. Ma and C. Xia, Chem. Commun., 2018, 54, 11033 DOI: 10.1039/C8CC06111D

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