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Issue 82, 2018
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Relay tricyclic Pd(II)/Ag(I) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR

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Abstract

Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(II)/Ag(I) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating six discrete chemical steps. The relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit EGFR, exhibit apoptosis through the ROS-induced mitochondrial-mediated pathway, and arrest the cell cycle at the G1 phase.

Graphical abstract: Relay tricyclic Pd(ii)/Ag(i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR

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Publication details

The article was received on 18 Jul 2018, accepted on 13 Aug 2018 and first published on 13 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC05845H
Citation: Chem. Commun., 2018,54, 11530-11533
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    Relay tricyclic Pd(II)/Ag(I) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR

    D. M. Sawant, S. Sharma, R. S. Pathare, G. Joshi, S. Kalra, S. Sukanya, A. K. Maurya, R. K. Metre, V. K. Agnihotri, S. Khan, R. Kumar and R. T. Pardasani, Chem. Commun., 2018, 54, 11530
    DOI: 10.1039/C8CC05845H

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