DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection

Liu Shi; Chaoli Mu; Tao Gao; Tianshu Chen; Shuang Hei; Jie Yang; Genxi Li

doi:10.1039/C8CC05690K

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DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection†

Liu Shi,‡^a Chaoli Mu,‡^a Tao Gao,^a Tianshu Chen,^b Shuang Hei,^a Jie Yang*^a and Genxi Li

*^ab

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* Corresponding authors

^a State Key Laboratory of Pharmaceutical Biotechnology and Collaborative Innovation Center of Chemistry for Life Sciences, Department of Biochemistry, Nanjing University, Nanjing 210093, P. R. China
E-mail: yangjie@nju.edu.cn, genxili@nju.edu.cn

^b Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

Abstract

By employing DNA nanoflower blooming in the nanochannels of porous anodic alumina (PAA), a nanochannel platform for microRNA (miRNA) detection has been proposed. Significant steric and electrostatic hindrance of the miRNA-initiated DNA-nanoflower growth may also amplify the signal readout for miRNA detection to give excellent sensitivity, selectivity and reproducibility.

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Article information

DOI: https://doi.org/10.1039/C8CC05690K
Article type: Communication
Submitted: 13 Jul 2018
Accepted: 29 Aug 2018
First published: 30 Aug 2018

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Chem. Commun., 2018,54, 11391-11394

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DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection

L. Shi, C. Mu, T. Gao, T. Chen, S. Hei, J. Yang and G. Li, Chem. Commun., 2018, 54, 11391 DOI: 10.1039/C8CC05690K

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Chemical Communications

DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection†

Abstract

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DNA nanoflower blooms in nanochannels: a new strategy for miRNA detection

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