Issue 68, 2018

A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

Abstract

A general two-step one-pot synthesis process of ynones was developed by cycloaddition of α-keto acids and 1-iodoalkynes followed by a ring-opening reaction. Its easy conditions and novel mechanism endowed it with two distinctive advantages: iodine-atom bonded to C(sp2) remained intact and α-keto acids became a part of the triple bonds in ynones.

Graphical abstract: A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

Supplementary files

Article information

Article type
Communication
Submitted
05 Jul 2018
Accepted
31 Jul 2018
First published
31 Jul 2018

Chem. Commun., 2018,54, 9517-9520

A general two-step one-pot synthesis process of ynones from α-keto acids and 1-iodoalkynes

X. Zeng, C. Liu, W. Yang, X. Wang, X. Wang and Y. Hu, Chem. Commun., 2018, 54, 9517 DOI: 10.1039/C8CC05429K

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