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Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

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Abstract

We introduce here hemiaminal ether linkages, synthesized by coupling a vinyl ether and a 1,2,3-triazole, as responsive groups in polymers to allow the selective release of a functional molecule. The release kinetics of benzotriazole from polymer nanoparticles shows a fast release at low pH values and a prolonged or even no release under mildly acidic conditions and at neutral pH.

Graphical abstract: Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

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Publication details

The article was received on 04 Jul 2018, accepted on 07 Nov 2018 and first published on 07 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC05386C
Citation: Chem. Commun., 2018, Advance Article
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    Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

    F. Seidi, V. Druet, N. Huynh, T. Phakkeeree and D. Crespy, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05386C

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