Issue 97, 2018

Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

Abstract

We introduce here hemiaminal ether linkages, synthesized by coupling a vinyl ether and a 1,2,3-triazole, as responsive groups in polymers to allow the selective release of a functional molecule. The release kinetics of benzotriazole from polymer nanoparticles shows a fast release at low pH values and a prolonged or even no release under mildly acidic conditions and at neutral pH.

Graphical abstract: Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

Supplementary files

Article information

Article type
Communication
Submitted
04 Jul 2018
Accepted
07 Nov 2018
First published
07 Nov 2018

Chem. Commun., 2018,54, 13730-13733

Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

F. Seidi, V. Druet, N. Huynh, T. Phakkeeree and D. Crespy, Chem. Commun., 2018, 54, 13730 DOI: 10.1039/C8CC05386C

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