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Issue 97, 2018
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Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

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Abstract

We introduce here hemiaminal ether linkages, synthesized by coupling a vinyl ether and a 1,2,3-triazole, as responsive groups in polymers to allow the selective release of a functional molecule. The release kinetics of benzotriazole from polymer nanoparticles shows a fast release at low pH values and a prolonged or even no release under mildly acidic conditions and at neutral pH.

Graphical abstract: Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

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Supplementary files

Article information


Submitted
04 Jul 2018
Accepted
07 Nov 2018
First published
07 Nov 2018

Chem. Commun., 2018,54, 13730-13733
Article type
Communication

Hemiaminal ether linkages provide a selective release of payloads from polymer conjugates

F. Seidi, V. Druet, N. Huynh, T. Phakkeeree and D. Crespy, Chem. Commun., 2018, 54, 13730
DOI: 10.1039/C8CC05386C

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