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Issue 63, 2018
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Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

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Abstract

Novel D–π–A–π–D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.

Graphical abstract: Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

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Publication details

The article was received on 30 Jun 2018, accepted on 09 Jul 2018 and first published on 12 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC05259J
Citation: Chem. Commun., 2018,54, 8717-8720
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    Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

    Y. Li, K. Wang, K. Zhou, W. Guo, B. Dai, Y. Liang, J. Dai and M. Cui, Chem. Commun., 2018, 54, 8717
    DOI: 10.1039/C8CC05259J

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