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Issue 64, 2018
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Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

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Abstract

An efficient protocol for oximinotrifluoromethylation of unactivated alkenes was developed via trifluoromethyl radical-induced intramolecular remote oximino migration under mild reaction conditions, providing a wide range of β-trifluoromethylated oximes. Other fluoroalkyl radicals were also applicable for this transformation. This method provided access to synthetically challenging medium-sized ring scaffolds and the 6,7,5-fused lactam skeleton.

Graphical abstract: Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

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Supplementary files

Article information


Submitted
28 Jun 2018
Accepted
17 Jul 2018
First published
18 Jul 2018

Chem. Commun., 2018,54, 8885-8888
Article type
Communication

Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

N. Wang, J. Wang, Y. Guo, L. Li, Y. Sun, Z. Li, H. Zhang, Z. Guo, Z. Li and X. Liu, Chem. Commun., 2018, 54, 8885
DOI: 10.1039/C8CC05186K

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