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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

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Abstract

Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

Graphical abstract: Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

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Publication details

The article was received on 28 Jun 2018, accepted on 08 Oct 2018 and first published on 09 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC05175E
Citation: Chem. Commun., 2018, Advance Article
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    Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

    H. Singh, S. J. Kim, D. H. Kang, H. Kim, A. Sharma, W. Y. Kim, C. Kang and J. S. Kim, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05175E

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