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CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

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Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

Graphical abstract: CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

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Publication details

The article was received on 20 Jul 2018, accepted on 17 Sep 2018 and first published on 12 Oct 2018


Article type: Communication
DOI: 10.1039/C8CC05113E
Citation: Chem. Commun., 2018, Advance Article
  • Open access: Creative Commons BY license
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    CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

    E. S. Hems, B. A. Wagstaff, G. Saalbach and R. A. Field, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC05113E

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