Issue 74, 2018

Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines

Abstract

The last two decades have witnessed the development of metal-catalyzed asymmetric additions of arylboronic acids to electron-deficient double bonds. Much research has been directed towards Rh(I)-catalysis because of the high activity of this transition metal for these types of reactions. Recently, significant advances have emerged in Pd(II), Ni(II), and Co(II)-catalyzed asymmetric additions of organoboron reagents. This feature article highlights the development of additions to ketimines catalyzed by these three metals, that is, (i) Pd(II)-catalyzed enantioselective additions of arylboronic acids to ketimines, (ii) Ni(II)-catalyzed enantioselective additions of arylboronic and alkenylboronic acids to ketimines, and (iii) Co(II)-catalyzed enantioselective additions of potassium allyltrifluoroborate to ketimines.

Graphical abstract: Pd(ii), Ni(ii) and Co(ii)-catalyzed enantioselective additions of organoboron reagents to ketimines

Article information

Article type
Feature Article
Submitted
20 Jun 2018
Accepted
25 Jul 2018
First published
26 Jul 2018

Chem. Commun., 2018,54, 10394-10404

Pd(II), Ni(II) and Co(II)-catalyzed enantioselective additions of organoboron reagents to ketimines

M. Quan, L. Wu, G. Yang and W. Zhang, Chem. Commun., 2018, 54, 10394 DOI: 10.1039/C8CC04932G

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