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Issue 74, 2018
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Synthesis of highly controlled carbohydrate–polymer based hybrid structures by combining heparin fragments and sialic acid derivatives, and solid phase polymer synthesis

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Abstract

Heparin is a polymeric carbohydrate with a variety of biomedical applications that is particularly challenging from a synthetic point of view. Here, we present the synthesis of carbohydrate–polymer based hybrid structures by combining defined heparin fragments with monodisperse, sequence-controlled glycooligo(amidoamines) suitable as glycan mimetic model compounds of heparin as demonstrated by STD-NMR binding studies with viral capsids.

Graphical abstract: Synthesis of highly controlled carbohydrate–polymer based hybrid structures by combining heparin fragments and sialic acid derivatives, and solid phase polymer synthesis

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Publication details

The article was received on 20 Jun 2018, accepted on 20 Aug 2018 and first published on 20 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC04898C
Citation: Chem. Commun., 2018,54, 10487-10490

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    Synthesis of highly controlled carbohydrate–polymer based hybrid structures by combining heparin fragments and sialic acid derivatives, and solid phase polymer synthesis

    M. Baier, J. L. Ruppertz, M. M. Pfleiderer, B. S. Blaum and L. Hartmann, Chem. Commun., 2018, 54, 10487
    DOI: 10.1039/C8CC04898C

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