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Issue 60, 2018
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ProTide generated long-acting abacavir nanoformulations

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Abstract

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

Graphical abstract: ProTide generated long-acting abacavir nanoformulations

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Publication details

The article was received on 14 Jun 2018, accepted on 02 Jul 2018 and first published on 11 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04708A
Citation: Chem. Commun., 2018,54, 8371-8374
  • Open access: Creative Commons BY-NC license
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    ProTide generated long-acting abacavir nanoformulations

    Z. Lin, N. Gautam, Y. Alnouti, J. McMillan, A. N. Bade, H. E. Gendelman and B. Edagwa, Chem. Commun., 2018, 54, 8371
    DOI: 10.1039/C8CC04708A

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