Issue 60, 2018
From the journal:

Chemical Communications

ProTide generated long-acting abacavir nanoformulations†

Zhiyi Lin,ab   Nagsen Gautam,b   Yazen Alnouti,b   JoEllyn McMillan,a   Aditya N. Bade,a   Howard E. Gendelman ORCID logo *ab  and  Benson Edagwa*a  

* Corresponding authors

a Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA
E-mail: hegendel@unmc.edu, benson.edagwa@unmc.edu

b Department of Pharmaceutical Science, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA

Abstract

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

Graphical abstract: ProTide generated long-acting abacavir nanoformulations

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Article information

DOI
https://doi.org/10.1039/C8CC04708A
Article type
Communication
Submitted
14 Jun 2018
Accepted
02 Jul 2018
First published
11 Jul 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 8371-8374

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ProTide generated long-acting abacavir nanoformulations

Z. Lin, N. Gautam, Y. Alnouti, J. McMillan, A. N. Bade, H. E. Gendelman and B. Edagwa, Chem. Commun., 2018, 54, 8371 DOI: 10.1039/C8CC04708A

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