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Issue 77, 2018
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Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

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Abstract

Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA–mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.

Graphical abstract: Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

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Publication details

The article was received on 11 Jun 2018, accepted on 25 Aug 2018 and first published on 27 Aug 2018


Article type: Communication
DOI: 10.1039/C8CC04635B
Citation: Chem. Commun., 2018,54, 10878-10881
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    Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs

    K. L. Chan, B. Peng, M. I. Umar, C. Chan, A. B. Sahakyan, M. T. N. Le and C. K. Kwok, Chem. Commun., 2018, 54, 10878
    DOI: 10.1039/C8CC04635B

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