Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide

Kortney M. Kersten; Meghan E. Breen; Anna K. Mapp; Adam J. Matzger

doi:10.1039/C8CC04530E

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Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide†

Kortney M. Kersten,

^a Meghan E. Breen,

^b Anna K. Mapp

^abc and Adam J. Matzger

*^ad

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA
E-mail: matzger@umich.edu

^b Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-1005, USA

^c Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109-1005, USA

^d Macromolecular Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109-1055, USA

Abstract

Antimicrobial functionality is introduced into a pharmaceutical formulation of miconazole while improving solubility. The work leverages hydrate formation propensity in order to produce hydrogen peroxide solvates. The ubiquity of hydrate formation suggests that hydrogen peroxide can be broadly deployed in pharmaceuticals, rendering a liquid excipient suitable for solid pharmaceutical formulations.

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Article information

DOI: https://doi.org/10.1039/C8CC04530E
Article type: Communication
Submitted: 06 Jun 2018
Accepted: 23 Jul 2018
First published: 26 Jul 2018

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Chem. Commun., 2018,54, 9286-9289

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Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide

K. M. Kersten, M. E. Breen, A. K. Mapp and A. J. Matzger, Chem. Commun., 2018, 54, 9286 DOI: 10.1039/C8CC04530E

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Chemical Communications

Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide†

Abstract

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Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide

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