Issue 66, 2018

Electrodrugs: an electrochemical prodrug activation strategy


The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(IV) prodrugs into their active Pt(II) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.

Graphical abstract: Electrodrugs: an electrochemical prodrug activation strategy

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Article information

Article type
24 May 2018
24 Jul 2018
First published
24 Jul 2018
This article is Open Access
Creative Commons BY license

Chem. Commun., 2018,54, 9242-9245

Electrodrugs: an electrochemical prodrug activation strategy

D. J. Norman, E. González-Fernández, J. Clavadetscher, L. Tucker, M. Staderini, A. R. Mount, A. F. Murray and M. Bradley, Chem. Commun., 2018, 54, 9242 DOI: 10.1039/C8CC04151B

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