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Issue 66, 2018
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Electrodrugs: an electrochemical prodrug activation strategy

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Abstract

The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(IV) prodrugs into their active Pt(II) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.

Graphical abstract: Electrodrugs: an electrochemical prodrug activation strategy

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Publication details

The article was received on 24 May 2018, accepted on 24 Jul 2018 and first published on 24 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04151B
Citation: Chem. Commun., 2018,54, 9242-9245
  • Open access: Creative Commons BY license
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    Electrodrugs: an electrochemical prodrug activation strategy

    D. J. Norman, E. González-Fernández, J. Clavadetscher, L. Tucker, M. Staderini, A. R. Mount, A. F. Murray and M. Bradley, Chem. Commun., 2018, 54, 9242
    DOI: 10.1039/C8CC04151B

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