Catalytic, metal-free alkylheteroarylation of alkenes via distal heteroaryl ipso-migration

Yonghui He; Yaqi Wang; Jun Gao; Liang Zeng; Shusheng Li; Wei Wang; Xiaohui Zheng; Shengyong Zhang; Lijun Gu; Ganpeng Li

doi:10.1039/C8CC03911A

Catalytic, metal-free alkylheteroarylation of alkenes via distal heteroaryl ipso-migration†

Yonghui He,^a Yaqi Wang,^a Jun Gao,^a Liang Zeng,^a Shusheng Li,^a Wei Wang,^a Xiaohui Zheng,^b Shengyong Zhang,^c Lijun Gu

*^a and Ganpeng Li*^a

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* Corresponding authors

^a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, Yunnan Province, P. R. China
E-mail: ganpeng_li@sina.com.cn

^b College of Life Science, Northwest University, Xi'an, Shanxi Province, P. R. China

^c School of Pharmacy, Fourth Military Medical University, Xi’an, Shanxi Province, P. R. China

Abstract

A new direct alkylheteroarylation of alkenes with simple alkylnitriles via distal heteroaryl ipso-migration has been accomplished under metal-free conditions, in which inexpensive alkylnitriles served as radical precursors, which together with ease of operation makes this process a very practical protocol.

Chemical Communications

Catalytic, metal-free alkylheteroarylation of alkenes via distal heteroaryl ipso-migration†

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Catalytic, metal-free alkylheteroarylation of alkenes via distal heteroaryl ipso-migration

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