Issue 63, 2018
From the journal:

Chemical Communications

A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy†

Lei Xing,‡abcd   Jia-Liang Zhang,‡ae   Tian-jiao Zhou,a   Yu-Jing He,a   Peng-Fei Cui,a   Jia-Hui Gong,a   Minjie Sun,a   Jin-Jian Lu, ORCID logo f   Zhangjian Huang, ORCID logo ad   Liang Jin*ag  and  Hu-Lin Jiang ORCID logo *abcd  

* Corresponding authors

a State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
E-mail: jianghulin3@gmail.com
Fax: +86-25-83271027
Tel: +86-25-83271027

b Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, China

c Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China

d Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, China

e Department of Pharmacy, Dong Fang Hospital (Fuzhou General Hospital), Medical College of Xiamen University, Xiamen University, Fouzhou 350025, China

f State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

g School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
E-mail: liangjin1975@cpu.edu.cn
Fax: +86-25-8327-1242
Tel: +86-25-8327-1242

Abstract

We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts remarkable co-delivery efficiency, increases tumour cell apoptosis and inhibits tumour cell proliferation in vitro and in vivo.

Graphical abstract: A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CC03720E
Article type
Communication
Submitted
08 May 2018
Accepted
13 Jul 2018
First published
13 Jul 2018

Chem. Commun., 2018,54, 8737-8740

Permissions

Request permissions

A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

L. Xing, J. Zhang, T. Zhou, Y. He, P. Cui, J. Gong, M. Sun, J. Lu, Z. Huang, L. Jin and H. Jiang, Chem. Commun., 2018, 54, 8737 DOI: 10.1039/C8CC03720E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements