Issue 53, 2018

Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification

Abstract

Herein, we have developed a distinctive electrochemical sensing platform for miRNA assay. Target miRNA initiates two cycles of polymerization, nicking, and displacement reactions, which lead to the variation of the distance between redox molecules and the electrode surface. In addition, a reductant is employed for further electrochemical amplification.

Graphical abstract: Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification

Supplementary files

Article information

Article type
Communication
Submitted
08 May 2018
Accepted
12 Jun 2018
First published
12 Jun 2018

Chem. Commun., 2018,54, 7366-7369

Electrochemical sensing of attomolar miRNA combining cascade strand displacement polymerization and reductant-mediated amplification

P. Miao, Y. Jiang, T. Zhang, Y. Huang and Y. Tang, Chem. Commun., 2018, 54, 7366 DOI: 10.1039/C8CC03698E

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