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Issue 68, 2018
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HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

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Abstract

This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

Graphical abstract: HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

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Publication details

The article was received on 04 May 2018, accepted on 31 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03614D
Citation: Chem. Commun., 2018,54, 9442-9445
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    HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

    J. Amato, T. W. Madanayake, N. Iaccarino, E. Novellino, A. Randazzo, L. H. Hurley and B. Pagano, Chem. Commun., 2018, 54, 9442
    DOI: 10.1039/C8CC03614D

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