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Issue 44, 2018
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Synthesis of tetronic acids from propargylic alcohols and CO2

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Abstract

A direct and practical synthesis of important tetronic acids from easily available propargylic alcohols and carbon dioxide is reported for the first time. This transition-metal-free transformation features high atom- and step-economy, mild reaction conditions, good functional group tolerance and high yield. Preliminary mechanistic studies suggest that the reaction proceeds via cyclization to give alkylidene cyclic carbonate, ring-opening and re-cyclization processes.

Graphical abstract: Synthesis of tetronic acids from propargylic alcohols and CO2

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Publication details

The article was received on 16 Apr 2018, accepted on 08 May 2018 and first published on 09 May 2018


Article type: Communication
DOI: 10.1039/C8CC03039A
Citation: Chem. Commun., 2018,54, 5610-5613
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    Synthesis of tetronic acids from propargylic alcohols and CO2

    G. Shen, W. Zhou, X. Zhang, G. Cao, Z. Zhang, J. Ye, L. Liao, J. Li and D. Yu, Chem. Commun., 2018, 54, 5610
    DOI: 10.1039/C8CC03039A

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