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Issue 43, 2018
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A new probe for detecting zinc-bound carbonic anhydrase in cell lysates and cells

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Abstract

We report the synthesis and application of a small molecule probe for carbonic anhydrase (CA) to track holo-CA in cell lysates and live-cell models of zinc dyshomeostasis. The probe displays a 12-fold increase in fluorescence upon binding to bovine CA and also responds to human CA isoforms.

Graphical abstract: A new probe for detecting zinc-bound carbonic anhydrase in cell lysates and cells

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Publication details

The article was received on 13 Mar 2018, accepted on 01 May 2018 and first published on 01 May 2018


Article type: Communication
DOI: 10.1039/C8CC02034E
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Chem. Commun., 2018,54, 5442-5445

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    A new probe for detecting zinc-bound carbonic anhydrase in cell lysates and cells

    R. Mehta, M. H. Qureshi, M. K. Purchal, S. M. Greer, S. Gong, C. Ngo and E. L. Que, Chem. Commun., 2018, 54, 5442
    DOI: 10.1039/C8CC02034E

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