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Issue 39, 2018
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Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

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Abstract

Here we report the design of membrane-active peptidomimetic molecules with a tunable arrangement of hydrophobic and polar groups. In spite of having the same chemical composition, the effective hydrophobicities of the compounds were different as a consequence of their chemical structure and conformational properties. The compound with lower effective hydrophobicity demonstrated antibacterial activity that was highly selective towards bacteria over mammalian cells. This study, highlighting the role in membrane selectivity of the specific arrangement of the different moieties in the molecular structure, provides useful indications for developing non-toxic antibacterial agents.

Graphical abstract: Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

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Publication details

The article was received on 09 Mar 2018, accepted on 17 Apr 2018 and first published on 18 Apr 2018


Article type: Communication
DOI: 10.1039/C8CC01926F
Citation: Chem. Commun., 2018,54, 4943-4946
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    Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

    M. M. Konai, S. Samaddar, G. Bocchinfuso, V. Santucci, L. Stella and J. Haldar, Chem. Commun., 2018, 54, 4943
    DOI: 10.1039/C8CC01926F

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