An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species

Huanhuan Fan; Lili Zhang; Xiaoxiao Hu; Zilong Zhao; Huarong Bai; Xiaoyi Fu; Guobei Yan; Li-Hui Liang; Xiao-Bing Zhang; Weihong Tan

doi:10.1039/C8CC01841C

An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species†

Huanhuan Fan,‡^a Lili Zhang,‡^a Xiaoxiao Hu,‡^b Zilong Zhao,^a Huarong Bai,^a Xiaoyi Fu,^a Guobei Yan,^b Li-Hui Liang,^c Xiao-Bing Zhang

*^a and Weihong Tan

^a

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* Corresponding authors

^a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, China
E-mail: xbzhang@hnu.edu.cn

^b College of Life Sciences, Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, China

^c Hunan Provincial People's Hospital, Changsha, China

Abstract

Herein, we developed a strategy to attack the cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to improve cellular sensitivity to reactive oxygen species through suppressing MTH1 protein in cancer cells.

Chemical Communications

An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species†

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An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species

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