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Issue 60, 2018
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Redox-responsive cisplatin nanogels for anticancer drug delivery

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Abstract

Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.

Graphical abstract: Redox-responsive cisplatin nanogels for anticancer drug delivery

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Publication details

The article was received on 05 Mar 2018, accepted on 02 Jul 2018 and first published on 03 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC01795F
Citation: Chem. Commun., 2018,54, 8367-8370
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    Redox-responsive cisplatin nanogels for anticancer drug delivery

    W. Zhang and C. Tung, Chem. Commun., 2018, 54, 8367
    DOI: 10.1039/C8CC01795F

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