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Issue 55, 2018
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Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

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Abstract

The aggregation of Aβ1–40 was monitored by solution NMR, which showed a trend complementary to the one observed by ThT-fluorescence. The NMR data support a kinetic model where Aβ1–40 initially aggregates with the reversible formation of oligomeric species, which then irreversibly convert into fibrils.

Graphical abstract: Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

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Publication details

The article was received on 20 Mar 2018, accepted on 03 May 2018 and first published on 16 May 2018


Article type: Communication
DOI: 10.1039/C8CC01710G
Citation: Chem. Commun., 2018,54, 7601-7604
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    Aggregation kinetics of the Aβ1–40 peptide monitored by NMR

    G. Bellomo, S. Bologna, L. Gonnelli, E. Ravera, M. Fragai, M. Lelli and C. Luchinat, Chem. Commun., 2018, 54, 7601
    DOI: 10.1039/C8CC01710G

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