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Issue 22, 2018
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Narrowing the diversification of supramolecular assemblies by preorganization

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Abstract

We designed and synthesized three phosphorylated peptides as precursors of the same peptide Nap-YYY. We found that different precursors led to different materials with almost identical chemical compositions at the final stages. Only Nap-YpYY could form very uniform nanofibers in a stable supramolecular hydrogel by enzyme-instructed self-assembly (EISA) at the physiological temperature (37 °C). In contrast, de-phosphorylation of the other two precursors (Nap-pYYY and Nap-YYpY) resulted in diverse nanostructures in metastable hydrogels with precipitates. The formation of uniform nanomaterials in the stable hydrogels was due to the preorganization property of the precursor Nap-YpYY, which facilitated rapid folding and accelerated the kinetics of hydrogelation of the resulting peptide Nap-YYY generated by the EISA process. Our study demonstrated the importance of the precursor for the self-assembly of nanomaterials and provided a useful strategy to manipulate them.

Graphical abstract: Narrowing the diversification of supramolecular assemblies by preorganization

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Publication details

The article was received on 07 Feb 2018, accepted on 19 Feb 2018 and first published on 19 Feb 2018


Article type: Communication
DOI: 10.1039/C8CC01082J
Citation: Chem. Commun., 2018,54, 2751-2754
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    Narrowing the diversification of supramolecular assemblies by preorganization

    Z. Wang, C. Liang, Y. Shang, S. He, L. Wang and Z. Yang, Chem. Commun., 2018, 54, 2751
    DOI: 10.1039/C8CC01082J

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