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Issue 15, 2018
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Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

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Abstract

BODIPY derivative, SF-1, exclusively shows a fluorescence ON response to HOCl and images endogenously generated HOCl in RAW 264.7 macrophages. Widefield and super resolution structured illumination microscopy images confirm localization in the Golgi complex and lysosomes, and hence specifically detects HOCl generated in these organelles. SF-1 is compatible with 3D-SIM imaging of individual cells.

Graphical abstract: Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

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Supplementary files

Article information


Submitted
12 Dec 2017
Accepted
25 Jan 2018
First published
31 Jan 2018

Chem. Commun., 2018,54, 1849-1852
Article type
Communication

Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

F. Ali, S. Aute, S. Sreedharan, H. A. Anila, H. K. Saeed, C. G. Smythe, J. A. Thomas and A. Das, Chem. Commun., 2018, 54, 1849
DOI: 10.1039/C7CC09433G

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