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Issue 15, 2018
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Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

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Abstract

BODIPY derivative, SF-1, exclusively shows a fluorescence ON response to HOCl and images endogenously generated HOCl in RAW 264.7 macrophages. Widefield and super resolution structured illumination microscopy images confirm localization in the Golgi complex and lysosomes, and hence specifically detects HOCl generated in these organelles. SF-1 is compatible with 3D-SIM imaging of individual cells.

Graphical abstract: Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

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Publication details

The article was received on 12 Dec 2017, accepted on 25 Jan 2018 and first published on 31 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC09433G
Citation: Chem. Commun., 2018,54, 1849-1852
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    Tracking HOCl concentrations across cellular organelles in real time using a super resolution microscopy probe

    F. Ali, S. Aute, S. Sreedharan, H. A. Anila, H. K. Saeed, C. G. Smythe, J. A. Thomas and A. Das, Chem. Commun., 2018, 54, 1849
    DOI: 10.1039/C7CC09433G

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