A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring

Abstract

A one-pot fuel cell for specific, enzyme-catalysed organic synthesis, with continuous monitoring of rate and reaction progress, combines an electrode catalysing rapid, reversible and diffusion-controlled interconversion of NADP⁺ and NADPH with a Pt electrode catalysing 2H⁺/H₂ interconversion. This Communication demonstrates its performance and characteristics using the reductive amination of 2-oxoglutarate as a test system.