Issue 16, 2018
From the journal:

Chemical Communications

Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation†

Arundhati Roy, ORCID logo ‡a   Amitosh Gautam,a   Javid Ahmad Malla,a   Sohini Sarkar,a   Arnab Mukherjee ORCID logo a  and  Pinaki Talukdar ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411008, India
E-mail: ptalukdar@iiserpune.ac.in

Abstract

This study reports the formation of self-assembled transmembrane anion channels by small-molecule fumaramides. Such artificial ion channel formation was confirmed by ion transport across liposomes and by planar bilayer conductance measurements. The geometry-optimized model of the channel and Cl− ion selectivity within the channel lumen was also illustrated.

Graphical abstract: Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation

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Article information

DOI
https://doi.org/10.1039/C7CC08693H
Article type
Communication
Submitted
11 Nov 2017
Accepted
05 Jan 2018
First published
05 Jan 2018

Chem. Commun., 2018,54, 2024-2027

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Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation

A. Roy, A. Gautam, J. A. Malla, S. Sarkar, A. Mukherjee and P. Talukdar, Chem. Commun., 2018, 54, 2024 DOI: 10.1039/C7CC08693H

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