Issue 4, 2018
From the journal:

Chemical Communications

Polymorphism of griseofulvin: concomitant crystallization from the melt and a single crystal structure of a metastable polymorph with anomalously large thermal expansion†

Yuan Su,a   Jia Xu,a   Qin Shi,a   Lian Yub  and  Ting Cai ORCID logo *ac  

* Corresponding authors

a State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China
E-mail: tcai@cpu.edu.cn

b School of Pharmacy and Department of Chemistry, University of Wisconsin, Madison, USA

c Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, China

Abstract

Griseofulvin (GSF) is a classic antifungal drug that has been in clinical use for over 50 years, but its polymorphism was recognized only recently via melt crystallization. Here we report the structure of a single crystal of GSF form II which was unusually harvested from the supercooled melt. GSF form II exhibits an anomalously large thermal expansion coefficient.

Graphical abstract: Polymorphism of griseofulvin: concomitant crystallization from the melt and a single crystal structure of a metastable polymorph with anomalously large thermal expansion

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Article information

DOI
https://doi.org/10.1039/C7CC07744K
Article type
Communication
Submitted
06 Oct 2017
Accepted
04 Dec 2017
First published
04 Dec 2017

Chem. Commun., 2018,54, 358-361

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Polymorphism of griseofulvin: concomitant crystallization from the melt and a single crystal structure of a metastable polymorph with anomalously large thermal expansion

Y. Su, J. Xu, Q. Shi, L. Yu and T. Cai, Chem. Commun., 2018, 54, 358 DOI: 10.1039/C7CC07744K

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