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Issue 12, 2018
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pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

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Abstract

At present, drug dosage is based on standardised approaches that disregard pharmakokinetic differences between patients and lead to non-optimal efficacy and unnecessary side effects. In this work, we demonstrate the potential of pH-mediated fluorescence spectroscopy for therapeutic drug monitoring in complex media. We apply this principle to the simultaneous quantification of the chemotherapeutic prodrug Irinotecan and its active metabolite SN-38 from human plasma across the clinically relevant concentration range, i.e. from micromolar to nanomolar at molar ratios of up to 30 : 1.

Graphical abstract: pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

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Publication details

The article was received on 02 Oct 2017, accepted on 08 Dec 2017 and first published on 23 Jan 2018


Article type: Communication
DOI: 10.1039/C7CC07668A
Chem. Commun., 2018,54, 1485-1488
  • Open access: Creative Commons BY license
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    pH-Mediated molecular differentiation for fluorimetric quantification of chemotherapeutic drugs in human plasma

    L. A. Serrano, Y. Yang, E. Salvati, F. Stellacci, S. Krol and S. Guldin, Chem. Commun., 2018, 54, 1485
    DOI: 10.1039/C7CC07668A

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