Issue 15, 2018
From the journal:

Chemical Communications

Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures†

C. Saintomé,‡ab   P. Alberti, ORCID logo ‡a   N. Guinot,a   P. Lejault,a   J. Chatain,a   P. Mailliet,a   J.-F. Riou ORCID logo a  and  A. Bugaut ORCID logo *a  

* Corresponding authors

a “Structure and Instability of Genomes” laboratory, Sorbonne Universités, Muséum National d’Histoire Naturelle (MNHN), Inserm U1154, CNRS UMR 7196, 75005 Paris, France
E-mail: abugaut@mnhn.fr

b UPMC Paris 6 Université, 75005 Paris, France

Abstract

Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.

Graphical abstract: Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

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Article information

DOI
https://doi.org/10.1039/C7CC07048A
Article type
Communication
Submitted
08 Sep 2017
Accepted
26 Jan 2018
First published
30 Jan 2018

Chem. Commun., 2018,54, 1897-1900

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Binding properties of mono- and dimeric pyridine dicarboxamide ligands to human telomeric higher-order G-quadruplex structures

C. Saintomé, P. Alberti, N. Guinot, P. Lejault, J. Chatain, P. Mailliet, J.-F. Riou and A. Bugaut, Chem. Commun., 2018, 54, 1897 DOI: 10.1039/C7CC07048A

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