Jump to main content
Jump to site search

Issue 10, 2018
Previous Article Next Article

An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation

Author affiliations

Abstract

The use of injectable materials as a biofiller for soft tissue augmentation has been increasing worldwide. Levan is a biocompatible and inexpensive polysaccharide with great potential in biomaterial applications, but it has not been extensively studied. In this study, we evaluated the potential of levan as a new material for dermal fillers and prepared an injectable and physical levan-based hydrogel by combining levan with Pluronic and carboxymethyl cellulose (CMC). A sol state was prepared by mixing the polymers in a specific ratio at 4 °C for 2 days and the hydrogel was formed by increasing the temperature to 37 °C. The elastic modulus of the levan hydrogel was higher than that of a hyaluronic acid (HA)-based hydrogel. The SEM images of the levan hydrogel showed an interconnected porous structure, similar to the HA hydrogel. Levan showed non-cytotoxicity, enhanced cell proliferation, and higher amount of collagen synthesis in human dermal fibroblast cells compared to HA. The injected levan hydrogel was biocompatible and stable over 2 weeks in vivo, longer than the Pluronic F127 hydrogel or HA hydrogel. Also, the levan hydrogel showed a higher amount of collagen production than the HA hydrogel in vivo. More importantly, the levan hydrogel showed enhanced anti-wrinkle efficacy compared to the HA hydrogel in a wrinkle model mouse. Thus, the levan hydrogel with injectability, biocompatibility, and an anti-wrinkle effect has high potential as an alternative to existing commercial dermal fillers.

Graphical abstract: An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation

Back to tab navigation

Supplementary files

Article information


Submitted
11 May 2018
Accepted
02 Aug 2018
First published
09 Aug 2018

Biomater. Sci., 2018,6, 2627-2638
Article type
Paper

An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation

W. I. Choi, Y. Hwang, A. Sahu, K. Min, D. Sung, G. Tae and J. H. Chang, Biomater. Sci., 2018, 6, 2627
DOI: 10.1039/C8BM00524A

Social activity

Search articles by author

Spotlight

Advertisements