Issue 21, 2018
From the journal:

Analytical Methods

Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine†

Ibrahim Kaya, ORCID logo ab   Eva Jennische,c   Stefan Langec  and  Per Malmberg ORCID logo *bd  

* Corresponding authors

a Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden

b The Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform, University of Gothenburg and Chalmers University of Technology, Gothenburg 412 96, Sweden
E-mail: malmper@chalmers.se

c Institute of Biomedicine, Gothenburg 413 90, Sweden

d Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg 412 96, Sweden

Abstract

Sensitive laser desorption/ionization obtained via a sublimation-coated 1,5-diaminonaphthalene (1,5-DAN) matrix allowed dual polarity MALDI-IMS analysis on the same pixel points across the jejunal mucosal region in rat small intestine which yielded high-spatial-resolution (10 μm) ion images of several lipid species correlated with the same histological features.

Graphical abstract: Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine

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Article information

DOI
https://doi.org/10.1039/C8AY00645H
Article type
Communication
Submitted
23 Mar 2018
Accepted
02 May 2018
First published
03 May 2018
This article is Open Access
Creative Commons BY-NC license

Anal. Methods, 2018,10, 2428-2435

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Dual polarity MALDI imaging mass spectrometry on the same pixel points reveals spatial lipid localizations at high-spatial resolutions in rat small intestine

I. Kaya, E. Jennische, S. Lange and P. Malmberg, Anal. Methods, 2018, 10, 2428 DOI: 10.1039/C8AY00645H

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