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Issue 29, 2018
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Preparation of nicotine surface molecularly imprinted polymers for selective solid-phase extraction of nicotine from zero-level refill liquids of electronic cigarettes

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Abstract

A new method of molecularly imprinted polymer solid-phase extraction (MISPE) coupled with gas chromatography-mass spectrometry was developed for the determination of nicotine in the zero-level refill liquids of electronic cigarettes. The surface molecularly imprinted polymers (SMIP) were synthesized on the surface of vinyl-SiO2 nanospheres using nicotine as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a cross-linker in toluene solution. The prepared SMIPs showed high adsorption capacity (247.0 μmol g−1), excellent imprinting factor (4.40), and high selectivity toward nicotine with selectivity coefficients higher than 2.9. Finally, the SMIPs were successfully utilized as solid-phase extraction (SPE) sorbents for the extraction of nicotine in the zero-level refill liquids of electronic cigarettes (ECs). The newly established method showed good linearity in the range of 2.00–40.00 μg mL−1. The limit of detection (LOD, S/N = 3) was 0.50 μg mL−1, the limit of quantification (LOQ, S/N = 10) was 1.66 μg mL−1, and the average recoveries range from 76.2% to 83.9% with relative standard deviations lower than 6.4% (n = 6). These results indicated that a feasible and reliable method was developed for the determination of nicotine in zero-level refill liquids of electronic cigarettes, which could provide an alternative solution for the quality control of electronic cigarette products.

Graphical abstract: Preparation of nicotine surface molecularly imprinted polymers for selective solid-phase extraction of nicotine from zero-level refill liquids of electronic cigarettes

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Publication details

The article was received on 20 Mar 2018, accepted on 11 Jun 2018 and first published on 22 Jun 2018


Article type: Paper
DOI: 10.1039/C8AY00616D
Citation: Anal. Methods, 2018,10, 3637-3644

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    Preparation of nicotine surface molecularly imprinted polymers for selective solid-phase extraction of nicotine from zero-level refill liquids of electronic cigarettes

    J. Xie, B. Zhou, T. Zhang, X. Zeng, M. Yang, W. Wang and J. Yang, Anal. Methods, 2018, 10, 3637
    DOI: 10.1039/C8AY00616D

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