Issue 6, 2018
From the journal:

Analytical Methods

A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS†

Jinlan Dong,a   Wenjing Ning,a   Daniel J. Mansa  and  Jamie D. Mans ORCID logo *a  

* Corresponding authors

a Division of Pharmaceutical Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, MO, USA
E-mail: Jamie.Mans@fda.hhs.gov

Abstract

A mixture of α-cyano-4-hydroxycinnamic acid and 1,5-diaminonaphthalene was discovered as a novel binary matrix for the qualitative analysis of 14 small-molecule (∼250–550 Da) cardiovascular drugs by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and MS/MS in either positive or negative ion mode.

Graphical abstract: A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS

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Article information

DOI
https://doi.org/10.1039/C7AY02583A
Article type
Communication
Submitted
03 Nov 2017
Accepted
20 Jan 2018
First published
01 Feb 2018

Anal. Methods, 2018,10, 572-578

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A binary matrix for the rapid detection and characterization of small-molecule cardiovascular drugs by MALDI-MS and MS/MS

J. Dong, W. Ning, D. J. Mans and J. D. Mans, Anal. Methods, 2018, 10, 572 DOI: 10.1039/C7AY02583A

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